Latest Clinical & Research News
Specialty: Endocrinology
Controlling a newly discovered pathway between the “anti-hunger” molecule N-lactoyl phenylalanine (Lac-Phe) and the widely prescribed diabetes drug metformin could lead to viable strategies to reduce body mass and improve health in millions of people. Lydia Lynch, PhD, and Marie McDonnell, MD, discuss their study.
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A Brigham and Women’s Hospital study suggests endoscopic sleeve gastroplasty (ESG) is cost-saving compared with semaglutide for class II obesity due to greater effectiveness and lower costs of ESG and increased dropout rates over time with semaglutide.
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A recent pooled analysis of randomized trials co-led by Brigham and Women’s Hospital researchers indicates that patients with type 2 diabetes who underwent bariatric surgery achieved better long-term blood glucose control compared to patients who received medical management plus lifestyle interventions.
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Vanita Aroda, MD, director of Diabetes Clinical Research at Brigham and Women’s Hospital, and colleagues report data from the latest study in the PIONEER clinical trial program that suggests higher doses of semaglutide are safe and efficacious for adults with type 2 diabetes who need additional glycemic control.
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Obstetrician Louise Wilkins-Haug, MD, PhD, and endocrinologist Ellen Seely, MD, are leaders at the Brigham’s Center for Connected Postpartum Care. The pair discusses the need for this center, its multidisciplinary approach to care, and its early successes in managing hypertensive patients postpartum.
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After analyzing data from pivotal trials, researchers at Brigham and Women’s Hospital believe treatment with a combination SGLT2i, GLP-1 RA, and nonsteroidal MRA has the potential to improve survival in patients with type 2 diabetes and at least moderately increased albuminuria.
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The Brigham was part of a trial that shows for the first time that the weight loss drug semaglutide lowers the incidence of death from cardiovascular causes in those with overweight or obesity but not diabetes. Jorge Plutzky, MD, discusses the findings and implications for clinical care.
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Using contemporary data sets reflecting current clinical practices, researchers at Brigham and Women’s Hospital developed the TIMI Risk Score for Atherothrombosis in Diabetes, which uses information readily available from the medical chart to predict atherothrombotic complications in patients with type 2 diabetes.
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Clinical guidelines recommend denosumab for people with osteoporosis with a high fracture risk. Now, researchers at Brigham and Women’s Hospital have associated denosumab use with a 32% decreased risk of type 2 diabetes compared with the use of an oral bisphosphonate.
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Brigham and Women’s Hospital researchers, and colleagues investigated the effect of combining pharmacotherapy with transoral outlet reduction. They demonstrate the combination is superior to either therapy alone and provides similar efficacy to surgical revision for weight gain after Roux-en-Y gastric bypass.
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