Latest Clinical & Research News
Specialty: Endocrinology
A study showed patients with a history of bariatric surgery had lower overall complication rates after spinal surgery than morbidly obese patients who did not have bariatric surgery. Now researchers report significant reductions in symptomatic spinal disorders and the need for spinal surgery after bariatric surgery.
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David J. Cote, MD, PhD, and Meir J. Stampfer, MD, DrPH, of the Channing Division of Network Medicine at Brigham and Women’s Hospital, and colleagues have conducted the first prospective study of associations between pituitary adenoma and the use of oral contraceptives or menopausal hormone therapy.
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In 2018, Pichamol Jirapinyo, MD, MPH, and Christopher C. Thompson, MD, developed a modified technique they call distal POSE—which involves placing plications primarily in the gastric body, sparing the fundus. They have published a one-year study, concluding distal POSE appears safe and effective for treating obesity.
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Vanita Aroda, MD, associate physician in the Division of Endocrinology, Diabetes and Hypertension, has served as a clinical researcher and clinical trialist for countless studies focused on preventing and treating type 2 diabetes. She discusses her involvement in the SELECT, PIONEER 1, REVITALIZE 1, and other trials.
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Endoscopists at Brigham and Women’s Hospital have conducted the first study in which plication endoscopic transoral gastric outlet reduction was combined with argon plasma coagulation to treat weight gain after Roux-en-Y gastric bypass.
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Researchers have shown that a novel molecular signature from a single blood sample can identify women at risk of preeclampsia months before presentation. They also report that molecular signatures accurately track gestational age, independently of clinical factors, and could advance the study of other complications.
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When the COVID-19 lockdown began, the Brigham’s Diabetes Management Program developed a protocol for reaching out to patients whose routine clinic visits were abruptly canceled. A study led by Marie E. McDonnell, MD, revealed two-way communication was necessary to re-engage patients in diabetes care after disruption.
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In October 2021, the FDA approved the Spatz3, the first adjustable intragastric balloon available in the U.S. Christopher C. Thompson, MD, at Brigham and Women’s Hospital, Barham Abu Dayyeh, MD, of the Mayo Clinic, and colleagues report on the manufacturer-sponsored trial that informed the FDA approval.
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Brianne A. Kent, PhD, Steven W. Lockley, PhD, and colleagues hypothesize that peripheral clocks exist in humans. They report that the circadian rhythms of certain peripheral metabolic markers—lipids and liver proteins—differ from that of melatonin, a principal marker of central pacemaker activity.
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The FREEDOM CVO trial investigated ITCA 650, an osmotic mini-pump that delivers a continuous subcutaneous infusion of exenatide. The primary efficacy outcome met the FDA’s prespecified criterion for noninferiority to placebo in a broad population of patients with T2D.
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