Study Explains Why Patients With Diabetes Are Prone to Thrombosis, Suggests New Therapeutic Target

Man puts on compression socks for thrombosis

An ion channel protein known as Piezo1 is known to facilitate thrombus formation, and researchers at Brigham and Women’s Hospital have shown it may represent a new target for therapies to prevent thrombosis in patients with type 2 diabetes mellitus who are at high risk.

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Novel Treatment May Improve Transplant Outcomes in Patients With Obesity

Bariatric surgery in operating room with surgeon looking at monitor

In a new study, Stefan G. Tullius, MD, PhD, of the Division of Transplant Surgery, Markus Quante, MD, of University Hospital Tuebingen, and colleagues present evidence that TDCA/valine may be a noninvasive alternative to bariatric surgery for improving transplant outcomes in patients with obesity.

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Oral Drug Developed at the Brigham Replicates Metabolic Benefits of Gastric Bypass

3d Rendering of gastric bypass on red background

Since many patients with diabetes are ineligible for RYGB or decline it, researchers at Brigham and Women’s Hospital developed an orally administered gut barrier coating for improving glucose homeostasis.

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Diagnosis Codes Suitable for Researching Obesity Using Claims-based Databases

Physician typing on laptop with clipboard/stethoscope on table

Researchers in the Brigham’s Division of Pharmacoepidemiology and Pharmacoeconomics, led by Elisabetta Patorno, MD, DrPH, have determined obesity-related International Classification of Disease (ICD) codes accurately identify patients with obesity in claims-based data.

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One-stage Approach to Converting Laparoscopic Adjustable Gastric Band to Sleeve Gastrectomy Found Safe, Effective

3D rendering of stomach with a gastric band

Scott Shikora, MD, director of Metabolic and Bariatric Surgery in the Center for Weight Management and Wellness at the Brigham, and colleagues conclude one-stage laparoscopic adjustable gastric band to sleeve gastrectomy conversion is safe and effective when performed by experienced surgeons.

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Laparoscopic Sleeve Gastrectomy Has Profound Effects on Immune Cells

3D rendering of laparoscopic sleeve gastrectomy

Research at Brigham and Women’s Hospital explored how laparoscopic sleeve gastrectomy improves the systemic inflammatory profile and found pronounced improvement in immune cell composition, function and metabolism, as measured by both biomarkers and gene expression, as soon as three months after the procedure.

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Examining the Impact of Carbohydrate Overfeeding on Metabolic Dysfunction

Close up of processed foods like pretzels, cookies, potato chips

By studying how cells from healthy normal weight and overweight participants broke down carbohydrates in real time, researchers including Brigham obesity medicine specialists Nawfal W. Istfan, MD, PhD, and Caroline M. Apovian, MD, have uncovered clues about what triggers metabolic distress.

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Striatin Deficiency Is Associated With Enhanced Thrombosis

3D Rendering of an Aldosterone Molecular Model

Jose R. Romero, PhD, and colleagues have now used a prevous model of patients with rs2540923 to show that striatin serves a protective role in the hemostatic system, which may be reduced in humans with striatin risk alleles.

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Biological Sex Modifies Aldosterone Secretion at a Cellular Level

3D Rendering of the Adrenal Gland

Gordon H. Williams, MD, senior physician in the Division of Endocrinology, Diabetes and Hypertension at the Brigham, Shadi K. Gholami, PhD, research fellow, and colleagues have expanded on their earlier work to determine if biological sex affects the production of aldosterone levels.

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Avoiding Long-Term Consequences of Gestational Diabetes

Ellen W. Seely, MD, director of clinical research in the Endocrinology, Diabetes and Hypertension Division, discusses the Brigham’s proactive approach to mitigating the impact of gestational diabetes on mothers, fetuses and newborn babies.

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