Drinkable Hydrogels Bridge the Gap Between Pills and Liquid Therapies

Gary W. Liu, PhD, Giovanni Traverso, MD, PhD, MBBCH, of the Division of Gastroenterology, Hepatology and Endoscopy at Brigham and Women’s Hospital, and colleagues show how a drinkable formulation called LIFT hydrogels could expand access to advanced therapeutics for people who have trouble swallowing pills.

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Endoscopic Sleeve Gastroplasty Saves Cost Compared With Semaglutide for Class II Obesity

A Brigham and Women’s Hospital study suggests endoscopic sleeve gastroplasty (ESG) is cost-saving compared with semaglutide for class II obesity due to greater effectiveness and lower costs of ESG and increased dropout rates over time with semaglutide.

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Liposomal Bupivacaine Is Good Alternative to Thoracic Epidural Analgesia for Patients Undergoing Minimally Invasive Lung Resection

Namrata Patil, MD, MPH, Anupama Singh, MD, and team compared thoracic epidural analgesia with injection of liposomal bupivacaine (LB) under direct witness in patients undergoing minimally invasive lung resection. LB intercostal block reduced opioid use 48 hours postoperatively and had fewer postoperative complications.

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Centrally Distributed Adiposity Linked to Higher Risk of Fecal Incontinence

Brigham and Women’s Hospital researchers and colleagues hypothesized that central adiposity, not elevated BMI alone, may have a role in fecal incontinence (FI). They report that waist circumference-to-height ratio (WtHR) is a stronger predictor of FI than BMI.

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Driving Innovation in Abdominal Wall Reconstruction

Throughout his career, new Brigham gastrointestinal surgeon O. Yusef Kudsi, MD, MBA, has embodied an entrepreneurial spirit most often seen in the business world. That characteristic helped him develop an international reputation as a hernia surgeon and a pioneer in robotic procedures for abdominal wall reconstruction.

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Bariatric Surgery Provides Long-Term Blood Glucose Control in Patients With Type 2 Diabetes

A recent pooled analysis of randomized trials co-led by Brigham and Women’s Hospital researchers indicates that patients with type 2 diabetes who underwent bariatric surgery achieved better long-term blood glucose control compared to patients who received medical management plus lifestyle interventions.

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Advancing the Understanding of Bariatric Surgery Outcomes

Members of the Brigham’s Department of Surgery served as authors of three recently published retrospective studies focused on bariatric surgery. Eric G. Sheu, MD, PhD, section chief of Bariatric and Foregut Surgery, and surgery resident Tina Bharani, MD, discuss the key clinical implications.

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What Prompts Bariatric Surgery Patients to Seek Care Again?

Brigham researchers conducted a first-of-its-kind retrospective study to better understand the subset of bariatric surgery patients who do not comply with recommended follow-ups that would help optimize long-term outcomes. Ali Tavakkoli, MD, chief of the Division of General and GI Surgery, discusses their findings.

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Analgesics for IBD Most Often Prescribed to Patients With Older Adult–Onset

Rahul S. Dalal, MD, MPH, at Brigham and Women’s Hospital, and colleagues recently completed a nationwide study of the use of analgesics for IBD according to age at disease onset. They report individuals with older adult–onset of IBD were more commonly prescribed analgesic medications, compared with other age groups.

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First-in-Human Trial: Ingestible Pill Accurately Monitors Respiration and Cardiac Activity

Ingestible devices have been researched since the 1950s, and proof-of-concept trials support their ability to measure pH, temperature, and gastrointestinal motility. Giovanni Traverso, MB, BChir, PhD, and colleagues have developed a vitamin-sized pill that measures respiratory rate and heart rate.

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