Brigham Team Discovers Mechanism of Th17 Cell Production in the Gut

Rendering of Interleukin 17, a cytokine produced by T-helper cells, on black background

Brigham and Women’s Hospital recently determined how epithelial cells promote Th17 cell generation in response to bacterial colonization as a step toward better understanding the treatment—and even prevention—of chronic inflammatory diseases.

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How Can Surgeons Contribute Once Their Operating Days Are Over?

Headshot of Pardon R. Kenney, MD, MS

After decades as a practicing surgeon, Pardon R. Kenney, MD, MS, was ready to step away from the operating room—but not from medicine or his love of teaching. In the Brigham’s new Section of Surgical Educators, he now shares the knowledge he has amassed with new medical students, residents, and attending physicians.

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The Brigham at Digestive Disease Week 2023

Speaker at Business Conference and Presentation. Audience at the conference hall.

Brigham and Women’s Hospital is honored to participate in the 2023 Digestive Disease Week (DDW) annual meeting on May 6-9 in Chicago, IL. This is the world’s premier meeting for physicians, researchers, and industry in the fields of gastroenterology, hepatology, endoscopy and gastrointestinal surgery.

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Endoscopic Gastric Plication Reduces Fibrosis in Patients With Obesity and NAFLD

Close up Doctor point out the computer screen, report of gastrointestinal endoscopy, medical imaging EGD looking for structures in the esophagus.Medical image concept.

Researchers at Brigham and Women’s Hospital have linked endoscopic gastric plication (also called distal primary obesity surgery endoluminal, or POSE) to significant improvement in liver-related outcomes in patients with obesity, nonalcoholic fatty liver disease, and clinically significant hepatic fibrosis.

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Clinical and Allergy Profiles of Eosinophilic Esophagitis Differ From GERD

Walter Chan, MD, PhD, of Brigham and Women’s Hospital, and colleagues have reported supporting evidence that proton pump inhibitor (PPI)–responsive eosinophilic esophagitis (EoE) is clinically similar to PPI-nonresponsive EoE and significantly different from erosive esophagitis.

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Durable Diabetes Remission More Likely After Bariatric Surgery Than Medical/Lifestyle Therapy

Team of surgeons in operating room

Few surgeons perform metabolic surgery for type 2 diabetes treatment, citing inadequate evidence, and for the same reason, many health insurance plans don’t cover it. Long-term supportive efficacy data from the largest randomized cohort has been published.

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Second-generation Transoral Incisionless Fundoplication Reduces Symptoms of Atypical GERD

A systematic review and meta-analysis by researchers at Brigham and Women’s Hospital indicates second-generation transoral incisionless fundoplication (TIF 2.0) is effective for atypical GERD (laryngopharyngeal reflux) and improves patient-centered outcomes.

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Multisystems Approach Identifies Environmental Chemicals That Promote Intestinal Inflammation

Researchers at Brigham and Women’s Hospital are using an integrated systems approach—a publicly available database, zebrafish chemical screens, machine learning and mouse models—to identify environmental chemicals that promote intestinal inflammation.

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Enhanced Recovery Pathway Boosting Postsurgical Outcomes in Peritoneal Metastasis Patients

Cytoreductive surgery (CRS) with hyperthermic intraperitoneal chemotherapy (HIPEC) has been shown to improve clinical outcomes and prognosis in patients with peritoneal metastasis. However, it is associated with a significant complication rate and a long postsurgical recovery in the hospital.
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