Latest Clinical & Research News
Specialty: Gastroenterology & GI Surgery
Endoscopists at Brigham and Women’s Hospital have conducted the first study in which plication endoscopic transoral gastric outlet reduction was combined with argon plasma coagulation to treat weight gain after Roux-en-Y gastric bypass.
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In the first study of its kind, Walter W. Chan, MD, PhD, at Brigham and Women’s Hospital, and colleagues identified “clusters” of patients with laryngeal symptoms who were evaluated for reflux.
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The Brigham’s Division of Gastroenterology, Hepatology and Endoscopy will present groundbreaking research at this year’s Digestive Disease Week conference in San Diego, CA.
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Developing better treatments for IBD requires understanding the underlying biological causes driving different forms of the disease. The Brigham’s Scott B. Snapper, MD, PhD, has devoted his research to this topic, which currently ranges from the creation of better mouse models to fostering early-stage clinical trials.
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Previous studies of GERD have relied on multichannel intraluminal impedance and pH testing, which has substantial limitations including the need to count reflux episodes. Now, researchers at Brigham and Women’s Hospital have linked more advanced impedance metrics to the prognosis of patients with IPF.
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Rachel W. Winter, MD, MPH, at Brigham and Women’s Hospital, and colleagues in Denmark conducted the largest study ever to evaluate weight change during TNF inhibitor therapy for patients with inflammatory bowel disease and report low weight gain overall with infliximab.
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In October 2021, the FDA approved the Spatz3, the first adjustable intragastric balloon available in the U.S. Christopher C. Thompson, MD, at Brigham and Women’s Hospital, Barham Abu Dayyeh, MD, of the Mayo Clinic, and colleagues report on the manufacturer-sponsored trial that informed the FDA approval.
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Brigham investigators are examining the link between the microbiota and colorectal cancer, including exploring how bariatric surgery changes the microbiome and the impact this connection may have on the development of colorectal cancer. James Yoo, MD, and Eric G. Sheu, MD, PhD, co-lead this new research initiative.
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Ali Abbas, MD, MPH, Christopher C. Thompson, MD, MSc, and colleagues report similar technical success rates for endoscopic ultrasound–guided gastroenterostomy (EUS-GE) and surgical gastrojejunostomy, despite more advanced cancer stage and worse performance status in the EUS-GE cohort.
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In a new study, Stefan G. Tullius, MD, PhD, of the Division of Transplant Surgery, Markus Quante, MD, of University Hospital Tuebingen, and colleagues present evidence that TDCA/valine may be a noninvasive alternative to bariatric surgery for improving transplant outcomes in patients with obesity.
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