Key Insight for Alzheimer’s Drug Design: Fibrils Are Abundant in Soluble Amyloid Beta
Researchers at Brigham and Women’s Hospital have redefined the nature of soluble Aβ, a key advance pertinent to future drug design for AD.
Read More...Category: Neurology & Neurosurgery
Specialty: Neurology & Neurosurgery
Case Report: Closed-Loop Neurostimulation of Multiple Thalamic Nuclei Controls Seizures
Closed-loop systems allow for concurrent sampling and modulation of extended thalamic networks. Researchers at Brigham and Women’s Hospital have become the first to capture continuous recordings of seizure activity from multiple thalamic nuclei using a closed-loop neurostimulation system.
Read More...Nasal Monoclonal Antibody Suppresses Inflammatory Response in COVID-19
In a new study, a Brigham team determined how nasal foralumab modulates inflammation and describes a potential novel avenue for treating not just COVID-19 but also autoimmune diseases.
Read More...Review: Myelin Oligodendrocyte Glycoprotein Antibody Disease
Various demyelinating diseases, including optic neuritis, transverse myelitis, acute disseminated encephalomyelitis (ADEM), and cerebral cortical encephalitis, are now recognized as a spectrum of diseases associated with high titers of autoantibodies that target myelin oligodendrocyte glycoprotein (MOG).
Read More...Economic Burden of Neuromyelitis Optica Spectrum Disorders Quantified From Patient Point of View
Brigham and Women’s Hospital researchers recently conducted the first study of patient-reported data on the economic burden of neuromyelitis optica spectrum disorders (NMOSD). Specifically, they characterized the direct and indirect costs of relapse events (ED visits and hospitalizations).
Read More...People Have “Massive” Memory for Where and When They Saw Something
Researchers at Brigham and Women’s Hospital have shown more specifically that humans have a spatial massive memory—they can remember where they saw objects presented briefly—and a temporal massive memory—they can remember when they saw the objects.
Read More...Delirium Superimposed on Dementia During Hospitalization Has Complex Effect on Costs
Tammy T. Hshieh, MD, MPH, and colleagues recently explored from a healthcare system perspective the direct costs of delirium in hospitalized patients with and without Alzheimer’s disease or a related disorder.
Read More...Somatic Variants in Supervillin Increase Susceptibility to Cerebral Aneurysms
Researchers at Brigham and Women’s Hospital recently reported that somatic variants—specifically, in the supervillin (SVIL) gene—increase susceptibility to intracranial aneurysms through changes in vascular smooth muscle cells (vSMCs).
Read More...AAN 2023: Brigham Neurologists Present Latest Research
On April 22–27, 2023, the American Academy of Neurology hosts its 75th annual meeting in Boston, MA and virtually. Leaders from the Department of Neurology at Brigham and Women’s Hospital will present their latest research at the meeting alongside international colleagues.
Read More...Brigham Neurosurgery at the AANS 2023 Annual Scientific Meeting
Experts from the Department of Neurosurgery at Brigham and Women’s Hospital join other neurosurgical leaders at this year’s AANS Annual Scientific Meeting, “Neurosurgeons as Advocates,” held April 21 – 24, 2023, in Los Angeles, CA.
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