Adults With TBI May Benefit From Screening for Cardiometabolic Disease, Other Comorbidities

Female doctor shows brain scan images to older male patient in hospital bed

An analysis of prospectively collected data has demonstrated that adults who sustain traumatic brain injury (TBI), regardless of age and injury severity, are at higher risk of certain cardiovascular, endocrine, neurologic, and psychiatric disorders.

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Review: Targeting Oncometabolism to Maximize Immunotherapy in Brain Cancer

Cells stained with different colors in a false color image of a tumour sample

Joshua D. Bernstock, MD, PhD, in the Department of Neurosurgery at Brigham and Women’s Hospital, Gregory K. Friedman, MD, of the University of Alabama at Birmingham, and colleagues reviewed novel therapies that target oncometabolism and tumor immunometabolism.

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Traumatic Brain Injury: a Chronic Disease That Affects More Than the Brain

Scientists and clinicians are starting to recognize links between traumatic brain injury and comorbidities such as cardiometabolic disease. Brigham associate neurologist Saef Izzy, MD, MBChB, discusses what he has observed in studying these links as well as possible implications for clinical care.

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Menopausal Hormone Therapy Linked to Increased Risk of Pituitary Adenoma

Woman sitting down holding a pack of menopausal hormone therapy pills

David J. Cote, MD, PhD, and Meir J. Stampfer, MD, DrPH, of the Channing Division of Network Medicine at Brigham and Women’s Hospital, and colleagues have conducted the first prospective study of associations between pituitary adenoma and the use of oral contraceptives or menopausal hormone therapy.

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Atlas of Migraine Cell Types Expected to Lead to Better Treatments

Migraine and related headache disorders activate peripheral sensory neurons in the trigeminal ganglion (TG). Researchers at Brigham and Women’s Hospital have now mapped the TG cell types in both humans and mice and the genes they express.

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Brigham Researchers Take a Closer Look at Lithium’s Effects on the Brain

Close up of a pile of pink lithium tablets with "223" imprinted on one side

Through brain imaging and laboratory research, Brigham investigators are examining how lithium affects the brain at the individual neuron and brain-circuit levels. Psychiatrist Amit Anand, MD, explains how it may increase the growth of certain areas of the brain and influence the organ functionally and structurally.

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Novel Therapeutic Target Identified for Multiple Sclerosis

Blue 3D rendering of microRNA strands

Researchers at the Ann Romney Center for Neurologic Diseases at the Brigham, and colleagues have affirmed miR-92a as a powerful, clinically relevant target in multiple sclerosis and give preliminary information about the effects of inhibiting miR-92a in central nervous system autoimmune disease.

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Making Headway in Targeting Glioblastoma Multiforme

Brain MRI showing a needle inserted into a glioblastoma multiforme tumor highlighted in purple

Break Through Cancer is a foundation that brings together elite cancer research centers to collaborate on and accelerate research, clinical trials and cures for deadly cancers, including glioblastoma multiforme. The Brigham’s Nathalie Y. R. Agar, PhD, and E. Antonio Chiocca, MD, PhD, discuss this ambitious undertaking.

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Sensitive Cognitive Outcomes Preclinical Alzheimer’s Disease Trials

3D rendering of Beta-amyloid found in Alzheimer's disease.

Kathryn V. Papp, PhD, and Reisa A. Sperling, MD, at Brigham and Women’s Hospital, and colleagues recently determined that very early Alzheimer’s disease is associated with a decline in existing measures of processing speed and memory retrieval.

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