Latest Clinical & Research News
Specialty: Neurology & Neurosurgery
Tracy Young-Pearse, PhD, Valentina Lagomarsino, Richard V. Pearse II, PhD, and colleagues have created a system that fills the gap between autopsy studies and genetic studies. They’ve shown that neurons derived from induced pluripotent stem cells (iPSCs) reflect molecular mechanisms underlying late-onset AD.
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Francisco J. Quintana, PhD, Cristina Gutiérrez-Vázquez, PhD, and colleagues engineered yeasts that generate an immunosuppressive molecule in direct proportion to the amount of a pro-inflammatory metabolite produced in the inflamed gut. They describe their new treatment platform and the results.
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Physicians at the Brigham are developing various treatments to improve seizure control for patients with epilepsy. As Garth Rees Cosgrove, MD, director of epilepsy and functional neurosurgery, explains, these therapies require a great deal of diagnostic and surgical expertise along with the latest cutting-edge tools.
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David J. Segar, MD, and G. Rees Cosgrove, MD, at Brigham and Women’s Hospital, and colleagues have reported the largest single-surgeon series of focused ultrasound thalamotomy to date. They demonstrate tremor relief and adverse event rates consistent with previous reports and present new information about predictors…
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By using a newer technique called lesion network mapping, Michael Ferguson, PhD, Michael D. Fox, MD, PhD, of the Center for Brain Circuit Therapeutics at Brigham and Women’s Hospital, and colleagues have identified a specific brain circuit that seems to be a neural substrate for spirituality and religiosity.
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Andrew J. Schoenfeld, MD, orthopedic surgeon at Brigham and Women’s Hospital, Elena Losina, PhD, co-director of the Brigham’s OrACORe, and colleagues conducted the first cost-effectiveness analysis of surgery for spinal metastases that accounts for ambulatory function at presentation.
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Christian D. Cerecedo-Lopez, MD, MS, and Rose Du, MD, PhD, at Brigham and Women’s Hospital, and colleagues estimate the U.S. incidence of acute myocardial infarction after aneurysmal subarachnoid hemorrhage is more than 12 times higher than previously reported.
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To determine when additional imaging may be advisable, Hasan A. Zaidi, MD, and Blake M. Hauser of the Computational Neurosurgical Outcomes Center in the Department of Neurosurgery at Brigham and Women’s Hospital, and colleagues identified common risk factors for thoracic and lumbar spinal fractures in TBI.
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Can targeting certain brain circuits with therapeutic stimulation modulate neuropsychiatric symptoms? A recent study involving multiple Brigham and Women’s Hospital investigators including Michael D. Fox, MD, PhD, and Shan H. Siddiqi, MD, MBBS, answers that crucial question in the affirmative.
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Brigham and Women’s Hospital investigators led by James D. Kang, MD, chair of the Department of Orthopaedic Surgery, and Shuichi Mizuno, PhD, are exploring new technology and a groundbreaking approach to slow down and even prevent intervertebral disc degeneration without resorting to surgery.
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