Improved Ingestible Sensor for Wireless Monitoring of the GI Tract Is Location-Aware

Doctor pointing to outline of gastrointestinal tract, GI

Researchers at Brigham and Women’s Hospital, MIT, and California Institute of Technology have devised a system for localizing and tracking wireless microdevices inside the GI tract in real-time and in non-clinical settings, with millimeter-scale spatial resolution and no need for X-ray radiation.

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Short- to Mid-term Survivorship of Patient-specific 3D-Printed UKA Implant Comparable to Conventional Implants

X-ray 3D medical anatomy of the knee illustration, knee arthroplasty concept

3D-printed patient-specific unicompartmental knee arthroplasty implants have become commercially available. Jeffrey K. Lange, MD, surgeon at Brigham and Women’s Hospital, and colleagues have published the first report on the short-term survivorship of this implant, which they found to be excellent.

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ENDO 2023: Brigham Leaders Present Latest Endocrinology Advancements

View from behind Audience at a conference hall, person presenting at podium

Leaders from the Division of Endocrinology, Diabetes and Hypertension at Brigham and Women’s Hospital are honored to join international colleagues at the world’s premier event in endocrinology research and clinical care: the Endocrine Society Annual Meeting. ENDO 2023 takes place June 15–18 in Chicago, IL.

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Paxlovid Reduces COVID-19 Hospitalization Among Vaccinated Older Adults

Older man holding glass of water and taking pill, paxlovid covid treatment concept

A Mass General Brigham study suggests nirmatrelvir plus ritonavir (Paxlovid) reduces COVID-19 severity even in highly vaccinated adults over the age of 50. In this Q&A, Scott Dryden-Peterson, MD, MSc, and Ann Woolley, MD, MPH, discuss key takeaways from the study and describe best methods for prescribing Paxlovid.

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Mouse PLPP6 Regulates Allergen Sensitization

Dendritic cell, antigen-presenting immune cell, 3D illustration

Brigham and Women’s Hospital researchers are the first to characterize Plpp6, a mouse homolog of PLPP6, as a polyisoprenyl diphosphate phosphatase that’s activated in dendritic cells after airway exposure to an aeroallergen. They suggest PLPP6 is likely a targetable regulatory checkpoint for allergic inflammation.

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Inflammation Versus LDL Cholesterol As Predictor of CV Events in Patients Using Statins

Young female doctor consults with senior male patient at hospital, in front of laptop

A collaborative analysis of 31,245 participants in three recent randomized trials suggests residual inflammatory risk is more strongly associated with future cardiovascular events than residual cholesterol risk.

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AAOS 2023: Mental Health Effects of Girdlestone Resection Arthroplasty

Healio spoke to Antonia Chen, MD, of the Department of Orthopaedic Surgery at Brigham and Women’s Hospital, about surgical outcomes research she presented at the 2023 annual meeting of the American Association of Orthopaedic Surgeons (AAOS) in Las Vegas.

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Machine Learning Algorithm Identifies Candidates for Hip and Knee Arthroplasty Without In‑Person Evaluation

Close up of doctor's hands on keyboard of laptop, electronic health record concept

Andrew K. Simpson, MD, MBA, MHS, at Brigham and Women’s Hospital, and colleagues created the first machine learning algorithm that identifies who may or may not be a potential candidate for hip or knee arthroplasty based solely on information that could be readily available in the electronic health record.

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Choroid Plexus Enlargement May Indicate Psychosis Onset

Because of the size, shape, and location of the choroid plexus (ChP), it’s difficult to use automated MRI to determine its volume. Brigham and Women’s Hospital researchers developed the first MRI manual segmentation method for investigating ChP, and they observed significant ChP enlargement in early-course psychosis.

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Using Video Interpretation to Enhance Care for Patients With Limited English Proficiency

Doctor and patient look at tablet, smiling; video interpretation in medical setting

Regan W. Bergmark, MD, a sinus and endoscopic skull base surgeon, is co-leading a project to advance language-concordant care in otolaryngology-head and neck surgery across the Mass General Brigham system. The team is trialing a mobile app that provides patients and physicians with live video interpretation on demand.

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