Centralized Protocol Improves Optimization of Guideline-Concordant Medical Therapy for HFrEF Patients Hospitalized for Any Reason

Doctor on laptop with stethoscope on table, electronic health record concept

A multicenter quality improvement study, IMPLEMENT-HF, shows that a centralized virtual team make suggestions to treating clinicians about caring for hospitalized patients with HFrEF improved the use of guideline-concordant medical therapy.

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Proof of Concept: Olfactory Function Visualized With EEG Plus Magnetoencephalography/MRI

In a proof-of-concept study, Stella E. Lee, MD, director of the Sinus Center in the Division of Otolaryngology–Head & Neck Surgery at Brigham and Women’s Hospital, and colleagues demonstrated a safe, portable, objective method for measuring smell function and its relationship with cognitive processing.

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Applying Engineering Expertise to Enrich Diagnostics, Therapy Planning, and Decision-making

Virtual surgery through numerical simulation of thoracic endovascular aortic repair implantation

Farhad R. Nezami, PhD, lead investigator in the Division of Cardiac Surgery at Brigham and Women’s Hospital, is a mechanical and aerospace engineer by training. His lab pulls from engineering, computer science, and bioinformatics to uncover better diagnostic tools and predictors of clinical events.

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Case Report: Hypertrophic Cardiomyopathy As an Unexpected Mimic of Inducible Laryngeal Obstruction

Close up of older man touching throat, discomfort, inducible laryngeal obstruction concept

Physicians at Brigham and Women’s Hospital recently encountered a patient with exertional dyspnea and inducible laryngeal obstruction at rest who was ultimately diagnosed with hypertrophic cardiomyopathy as the cause of his symptoms.

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Antibody Response to COVID-19 Vaccination Not Affected by Whether RA Patients Interrupt DMARD Therapy

Doctor giving senior female patient the COVID-19 vaccine

In an observational study in “real-world” practice, Brigham and Women’s Hospital researchers did not identify significant differences in antibody response to COVID-19 vaccination among rheumatoid arthritis patients who held versus continued disease-modifying anti-rheumatic drugs for the last dose of the primary series.

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How Can Surgeons Contribute Once Their Operating Days Are Over?

Headshot of Pardon R. Kenney, MD, MS

After decades as a practicing surgeon, Pardon R. Kenney, MD, MS, was ready to step away from the operating room—but not from medicine or his love of teaching. In the Brigham’s new Section of Surgical Educators, he now shares the knowledge he has amassed with new medical students, residents, and attending physicians.

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Delirium Superimposed on Dementia During Hospitalization Has Complex Effect on Costs

senior male patient with IV

Tammy T. Hshieh, MD, MPH, and colleagues recently explored from a healthcare system perspective the direct costs of delirium in hospitalized patients with and without Alzheimer’s disease or a related disorder.

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MIRROR Trial: Addition of Methotrexate to Pegloticase Is Efficacious, Safe

Doctor administers infusion therapy to patient sitting on chair, pegloticase infusion concept

Michael E. Weinblatt, MD, and colleagues are conducting the first randomized, placebo-controlled study using an immunomodulator with pegloticase to increase urate-lowering response durability. Initial findings confirm the superiority of pegloticase plus methotrexate co-therapy to pegloticase monotherapy.

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Initial Experience Supports Use of Silk–Hyaluronic Acid for Vocal Fold Injection Augmentation

The vocal folds

Christopher D. Dwyer, MD, Thomas L. Carroll, MD, and colleagues present the first publication to describe the use of Silk–HA (Silk Voice) for augmenting vocal fold tissue for phonation improvement in patients, including clinical pearls and suggestions for the informed consent process.

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Somatic Variants in Supervillin Increase Susceptibility to Cerebral Aneurysms

Human brain 2d digital illustration

Researchers at Brigham and Women’s Hospital recently reported that somatic variants—specifically, in the supervillin (SVIL) gene—increase susceptibility to intracranial aneurysms through changes in vascular smooth muscle cells (vSMCs).

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