Latest Clinical & Research News
Clinicians in the Department of Gastroenterology, Hepatology and Endoscopy at Brigham and Women’s Hospital and colleagues explored the prevalence and perceptions of the GI hospitalist model in academic GI departments across the United States. They report GI hospitalists are relatively common and geographically diverse.
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In-person exercise programs are well-established to effectively reduce pain in patients with knee osteoarthritis (OA). Elena Losina, PhD, and colleagues recently explored whether the same is true of remote exercise programs.
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In this Medical Grand Rounds presentation, Naomi D.L. Fisher, MD, of Brigham and Women’s Hospital, joined a panel of colleagues from the Boston area to discuss recent developments in the diagnosis and treatment of hypertension among older adults.
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Mass General Brigham researchers have demonstrated an algorithm-based cardiovascular risk management program delivered remotely is scalable at a population level and can meet the needs of diverse patient populations.
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Researchers at Brigham and Women’s Hospital hypothesized that differences in mucosal gene transcript expression might explain the differences in PPI treatment response. Instead, they found the transcriptional profiles in patients with PPI-responsive and -nonresponsive eosinophilic esophagitis are remarkably similar.
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Propranolol, the current standard of care for essential tremor (ET), has significant shortcomings in efficacy and safety. As medicinal chemist Kevin Hodgetts, PhD, explains, Brigham investigators are developing novel therapies for ET patients by applying innovative drug design concepts to validated disease targets.
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Researchers wondered whether the Kansas City Cardiomyopathy Questionnaire (KCCQ), a health status questionnaire for patients with heart failure, could be useful to monitor worsening pulmonary congestion remotely. They found no significant associations between KCCQ total symptom score and objective congestion markers
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Colleagues from the Brigham’s Center for Adrenal Disorders assessed the efficacy of aldosterone antagonism with a mineralocorticoid receptor (MR) antagonist versus placebo in patients with primary hyperparathyroidism (P-HPT). They provide evidence that MR antagonists have no meaningful role in P‐HPT treatment.
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Based on findings from a novel mouse model, researchers at Brigham and Women’s Hospital led by Ursula B. Kaiser, MD, suggest that genetic variants resulting in increased MKRN3 expression may be a previously unrecognized cause of delayed puberty.
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Michael J. Weaver, MD, and colleagues recently became the first to project the cost implications of severe obesity for treating lower extremity fractures, along with studying its effect on complications and healthcare utilization.
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