Focused Ultrasound Facilitates Delivery of Anti-Amyloid Antibody in Mouse Model of Alzheimer’s Disease

Amyloid plaques forming between neurons in a brain with Alzheimer's disease

Researchers at Brigham and Women’s Hospital are investigating therapeutic focused ultrasound to enhance antibody delivery to the brain when treating Alzheimer’s disease.

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Meta-analysis: Stroke Response Times Early in COVID-19 Depended on Metric, Type of Center

Elderly man in wheelchair in front of hospital windows, with female nurse wearing mask and gloves

Delays in stroke treatment were inevitable during the early months of the COVID-19 epidemic, given virus-related precautions and the massive influx of COVID-19 patients into hospitals. Understanding the precise extent of those delays is important to learn what factors lead to late care.

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Recombinant Lecithin-Cholesterol Acyltransferase Does Not Reduce Infarct Size or Plaque Volume in Acute STEMI

Coronary angiogram showing chronic total occlusion (CTO) of left anterior descending artery (LAD)

Marc S. Sabatine, MD, MPH, at Brigham and Women’s Hospital, and colleagues have completed a phase 2b trial of MEDI6012 in patients with STEMI. They report that MEDI6012 was not associated with significant reductions in infarct size or regression of noncalcified coronary plaque.

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Polarization-Sensitive OCT Technically Feasible for Assessing Pre-Osteoarthritis

Female patient at ophthalmologist leaning toward machine for optical coherence tomography testing

Mass General Brigham clinicians and colleagues showed polarization-sensitive optical coherence tomography (PS-OCT) can be performed minimally invasively and report results from a pilot study that will inform a large clinical trial to determine whether PS-OCT can predict the development of osteoarthritis.

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The Brigham’s Rheumatology Division Presents at ACR 2022

Headshot of Ellen M. Gravallese, MD

Members of the Division of Rheumatology, Inflammation and Immunity at Brigham and Women’s Hospital presented over 120 lectures and poster presentations at the 2022 American College of Rheumatology’s annual convergence conference. Learn more about a few of their cutting-edge presentations.

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Angled Fiber Tips Improve Anatomic Access in Models of In-Office Laser Treatment of the Larynx

3D rendering of larynx anatomy in throat of human being, highlighted orange

In two high-definition larynx models, Chan and colleagues recently demonstrated that side-firing laser fibers may substantially increase endoscopic access to difficult lesions. Now, researchers at Brigham and Women’s Hospital have built on that work, corroborating the results in additional, more varied anatomic models.

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Delphi Process Determines Best Practices for Laryngopharyngeal Reflux Disease Treatment

Woman standing holding chest highlighted in red for laryngopharyngeal reflux disease discomfort

Thomas L. Carroll, MD, section chief of Laryngology and director of the Voice Program at Brigham and Women’s Hospital, and colleagues recently completed a Delphi process to develop guidance about treating laryngopharyngeal reflux disease (LPR). They report their consensus.

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Left Ventricular Assist Device Therapy Comes of Age at the Brigham

The Brigham is giving advanced heart failure patients a new option that parallels the life prolongation of heart transplantation: implantation of a fully magnetically levitated left ventricular assist device. Mandeep R. Mehra, MD, and Akinobu Itoh, MD, PhD, are at the forefront of these efforts.

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Remote Physician Visits for Hospital-level Care at Home Generally Noninferior to In-Home Visits

Female patient speaking to doctor via virtual telehealth appointment on laptop

David M. Levine, MD, MPH, MA, and Jeffrey L. Schnipper, MD, MPH, of the Division of General Internal Medicine & Primary Care, and colleagues found patients who received predominantly remote physician care via videoconference had a noninferior number of adverse events compared with those who had only in-home care.

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Novel Approach Protects Animal Model Against Bacterial Pneumonia After Influenza A Infection

3D rendering of human lung anatomy, showing rod-shaped bacteria inside lung aveoli

Brigham researchers believe a new host-directed treatment approach to secondary bacterial pneumonia, a serious and common complication of infection with the influenza A virus (IAV) that can also occur after SARS-CoV-2 infection, might complement antibiotic therapy.

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