Latest Clinical & Research News
The Brigham’s Division of Thoracic Surgery launched a care continuum collaborative in 2011 to monitor the progress of patients discharged to Spaulding Rehabilitation Hospital after thoracic surgery. Namrata Patil, MD, MPH, details why she founded the collaboration and its beneficial impact on patient care.
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Minimally invasive surgery is often promoted as a way to reduce postoperative pain after benign gynecological surgery. However, Brigham researchers found vaginal and laparoscopic hysterectomy for treatment of pelvic organ prolapse appear to be similar with regard to postoperative pain medication requirements.
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The Brigham’s Jamie Coborn, PhD, Hadine Joffe, MD, and colleagues have published empirical evidence that changing hormone dynamics underlie awakenings in perimenopausal women, independent of vasomotor symptoms.
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Johanna Seitz-Holland, PhD, Marek Kubicki, MD, PhD, of the Department of Psychiatry at the Brigham, and colleagues recently became the first to investigate cognitive deficits in schizophrenia in a large-scale, thoroughly harmonized sample.
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High-resolution anoscopy can be a helpful tool for identifying precancerous lesions in the anal canal. Colon and rectal surgeon James Yoo, MD, and infectious disease specialist Jennifer A. Johnson, MD, both of the Brigham, developed and recently hosted a course to educate colorectal fellows on the technique.
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The Brigham’s Fengfeng Bei, PhD, and team have reported on a new adeno-associated virus variant that delivers gene therapy across the blood-brain barrier in non-human primates more efficiently than previously developed vehicles. It could have implications for treating neurodegenerative diseases including Alzheimer’s.
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Brigham researchers recently completed the first proteomic analysis in patients with rheumatoid arthritis and interstitial lung disease (RA-ILD). They identify molecular signatures strongly associated with the presence and severity of RA-ILD and provide insight into unexplored disease pathways.
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To address conflicting evidence, Meryl S. LeBoff, MD, JoAnn E. Manson, MD, PhD, MPH, and colleagues conducted an ancillary analysis of the Vitamin D and Omega-3 Trial (VITAL). They found vitamin D did not affect fracture risk in the general population.
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Many IVF programs freeze embryos to mitigate risk of elevated estradiol levels that can negatively affect conception and live birth. However, Brigham researchers determined elevated estradiol levels at the time of progesterone initiation have similarly negative effects on outcomes after frozen embryo transfer cycles.
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Scott D. Solomon, MD, director of the Clinical Trials Outcomes Center at Brigham and Women’s Hospital, and colleagues have concluded that SGLT2 inhibitors should be considered adjunctive therapy for all patients with heart failure, regardless of ejection fraction or care setting.
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