No Association Detected Between Cystic Lesions of the Pineal or Pituitary Gland

3D pink glowing outline of human brain with pineal gland highlighted

Because of imaging advances, incidental diagnosis of midline intracranial neuroendocrine cystic masses is increasingly common. Edward Laws, MD, of the Pituitary and Neuroendocrine Program at Brigham and Women’s Hospital, and colleagues examined whether there’s a link between Rathke cleft cysts and pineal gland cysts.

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VITAL Study Findings Show Vitamin D3 and Omega-3 Fatty Acids Do Not Reduce Frailty Risk

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After analyzing data from the VITamin D and OmegA-3 TriaL (VITAL), Brigham investigators have concluded that neither vitamin D3 nor omega-3 fatty acid supplementation prevents frailty in generally healthy older adults. Ariela Orkaby, MD, MPH, corresponding author of the new ancillary study, discusses the findings.

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Insurance Status Correlates With Patient-reported Baseline Symptoms of Adult Spinal Deformity

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In a study of patients with lumbar spinal stenosis, researchers at Brigham and Women’s Hospital previously demonstrated that patients insured by Medicaid have worse baseline PROMs than those commercially insured or insured by Medicare. Now, they’ve found the same is true in the setting of adult spinal deformity (ASD).

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Genotype Influences Heart Failure Pathways

RNA macromolecule skeletal formula, molecular structure of RNA single strand

An international research team co-led by Christine E. Seidman, MD, found that molecular and cellular mechanisms of heart failure in patients with dilated cardiomyopathy or arrhythmogenic cardiomyopathy were determined by the specific gene variant each individual carried.

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Can a Fatty Acid Supplement Improve Outcomes in People With Obesity and Prediabetes?

Yellow oil capsules spilling out of brown bottle onto table

Brigham researchers are looking at novel ways to boost natural mechanisms that the body uses to counteract the pathogenesis of obesity and its complications. An upcoming clinical trial led by Mehmet Furkan Burak, MD, explores the impact of dietary supplementation with palmitoleic acid in obese, prediabetic individuals.

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Up to One-Half of Runners Return to Running One Year After Arthroscopic Partial Meniscectomy

3D rendering of human knee bone and cartilage with meniscus tear highlighted red

Researchers at Brigham and Women’s Hospital determined that within one year after arthroscopic partial meniscectomy (APM), approximately 50% of runners return to their preoperative running frequency.

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Symptoms of Suspected Laryngopharyngeal Reflux Correlate Poorly With Hypopharyngeal–Esophageal Multichannel Intraluminal Impedance–pH

Woman sitting holding chest and stomach, red highlight on upper chest for reflux discomfort

Sanjay Salgado, MD, Walter W. Chan, MD, PhD, and colleagues recently found no correlation between suspected laryngopharyngeal reflux symptoms and hypopharyngeal–esophageal multichannel intraluminal impedance–pH (HEMII-pH) results.

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Novel Method of Delivering Therapeutic CO Fights Inflammation

Medically accurate rendering of inside an inflammed colon

Giovanni Traverso, MD, PhD, MBBCH, of Brigham and Women’s Hospital and MIT, and colleagues have incorporated CO into gas-entrapping materials (GEMs) that can be delivered safely to the digestive tract.

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Oil-based Gels Are Versatile Drug Delivery Systems for Pediatric Applications

Male pediatrician listening to boy's heart through stethoscope in medical setting

Ameya Kirtane, PhD, and Giovanni Traverso MD, PhD, MBBCH, and colleagues have developed oleogels—gels made from food-based oils—that can be used to deliver drugs to children. They report oleogels may perform similarly to or better than commercial tablets.

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