Blood Metabolomic Profiles May Predict Outcomes of Endometriosis Surgery in Adolescents and Young Adults

Young Black woman sitting on edge of bed holding abdomen in pain, pelvic pain endometriosis concept

About one-third of patients with endometriosis have persistent pelvic pain after surgical treatment. Brigham and Women’s Hospital researchers have conducted the first study of the relationship between presurgical blood metabolites and postsurgical pain in adolescents and young women with endometriosis.

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Operative Time Influences Rate of Complications After Radical Cystectomy

Blue rendering with urinary system anatomy highlighted including kidneys and bladder

Radical cystectomy (RC) is a complex procedure requiring the urinary system’s reconstruction. Brigham and Women’s Hospital researchers, including Lorine Haeuser, MD, and Matthew Mossanen, MD, MPH, report higher complication rates after both extremely short and extremely long RC procedures.

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Sleep Disturbances After Rotator Cuff Repair Usually Resolve Within Six Months

Elderly man leaning back holding left arm where pain is highlighted red coming from upper shoulder

In a large sample of prospectively collected data, researchers at Brigham and Women’s Hospital found that sleep patterns returned to normal within two years after surgery in 81% of patients and within six months in 77%.

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Dana-Farber Brigham Research Suggests Benefit in Flipping Current Guideline for Treating Post-Prostatectomy Patients

MRI image of prostate cancer

Investigators at Dana-Farber Brigham Cancer Center have uncovered a potentially serious flaw in the current standard of care for patients with positive pelvic node prostate cancer (pN1 PC). They found that adjuvant radiation therapy (aRT) is associated with a decreased risk of death compared with early salvage radiation therapy (sRT) in men with four or more positive lymph nodes. Moreover, the reduction increases by 8% for each additional positive pelvic lymph node found at surgery. Read More

Glioblastoma: Creating a Viral Oasis in an Immune Desert

Dana-Farber Brigham Cancer Center is world-renowned for its commitment to cutting-edge research. Over the years, its researchers have turned scientific discoveries into life-saving treatments, contributing to the development of 35 of 75 cancer drugs recently approved by the FDA for use in cancer patients. Read More

Dana-Farber Brigham Shaping the Future of Head and Neck Cancer Treatment

Over the last few decades, Dana-Farber Brigham Cancer Center has advanced the care and management of head and neck cancer patients through a collaborative, multidisciplinary approach. The team has focused on surgical innovations such as free flap reconstruction and minimally-invasive transoral robotic surgery to help patients recover their speech and swallowing functions while delivering highly effective and state-of-the-art therapeutic interventions. Advances in chemotherapy, immunotherapy, and radiation delivery techniques have clearly helped to improve patient outcomes. Read More

Proximity of Metacarpal Plates to Adjacent Joints Increases Risk of Implant Removal

Two views of X-ray of human hand with fracture in fifth metacarpal highlighted red

Internal fixation with plates and screws is commonly used to treat isolated metacarpal fractures but can cause stiffness and requires subsequent hardware removal. Brigham and Women’s Hospital researchers and colleagues studied factors associated with implant removal in this setting.

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Factors Predicting 30-Day Readmission of Substance Users With Acute Pancreatitis

3D rendering of human anatomy showing pancreas highlighted in red

Brigham and Women’s Hospital researchers recently conducted the first comprehensive study on healthcare utilization and readmission among U.S. patients with acute pancreatitis who use opioids and report on several factors that predicted 30-day readmission in this population.

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Response to Electroconvulsive Therapy for Major Depressive Disorder May Be Mediated by IL-8, White Matter Alterations

Diffusion MRI of a human brain. Brain fibers are highlighted in blue, green, yellow and pink

Researchers at Brigham and Women’s Hospital have related acute neuroinflammatory response and changes in white matter structure after electroconvulsive therapy to each other and treatment outcomes.

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Age-related Remodeling of Left Atrium Associated With Subclinical Infarcts, Stroke in Absence of AF

Blue 3D rendering of male human body with echocardiography device examining the heart

Brigham researchers have demonstrated that in an older population with normal ejection fraction and sinus rhythm, age‐related left atrium reservoir dysfunction and stiffness—detectable on three-dimensional echocardiography (3DE)—were associated with higher odds of subclinical cerebral infarcts (SCIs) and stroke.

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