Editorial: Meaningless Applications and Misguided Methodologies of AI-Related Research in Orthopedics

Researcher working on multiple displays showing artifical intelligence, machine learning concept

Prem N. Ramkumar, MD, MBA, of the Orthopaedic Machine Learning Laboratory at Brigham and Women’s Hospital, and colleagues want orthopedic surgeons to understand artificial intelligence (AI) better but critically assess AI-related reporting in the medical literature.

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Brigham Offering Magnetic Sphincter Augmentation for Patients With GERD

LINX product shown banded around a diagram of the lower esophageal sphincter above stomach

Magnetic sphincter augmentation using the LINX® Reflux Management System is an alternative to acid suppression therapy with proton pump inhibitors or traditional surgical treatment. Gastrointestinal and bariatric surgeons Thomas C. Tsai, MD, MPH, and David Spector, MD, discuss bringing this procedure to the Brigham.

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Novel AI Model Helps Detect Cardiac Allograft Rejection From Endomyocardial Biopsies

Hematoxylin and eosin–stained biopsy of muscle fibers of heart myocardium

Researchers at Brigham and Women’s Hospital have created Cardiac Rejection Assessment Neural Estimator (CRANE), a form of artificial intelligence for automated screening of endomyocardial biopsy results. They describe its performance and its potential to serve as an assistive diagnostic tool.

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Cocoa Extract Supplementation Shows Promise in Reducing Cardiovascular Events

Top view close up of many cocoa seeds

Researchers conducted the first rigorous, large-scale trial of long-term cocoa flavanol supplementation to prevent CVD and cancer. They found that cocoa extract supplementation led to a small but nonsignificant reduction in total cardiovascular events among older adults but significantly reduced CVD death by 27%.

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The Brigham Presents Four Late-breaking Clinical Trials at ACC 2022

Three headshots of Drs. Brian Bergmark, Deepak Bhatt, and Paul Ridker

Three cardiologists from the Division of Cardiovascular Medicine at the Brigham’s Heart & Vascular Center—Brian A. Bergmark, MD, Deepak L. Bhatt, MD, MPH, and Paul M. Ridker, MD, MPH—presented a total of four late-breaking clinical trials at the American College of Cardiology’s 71st Annual Scientific Session in April.

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Tiny Devices, Big Insights: A New Way to Predict Drug Response in Prostate Tumors

Researcher looking at microscope

Brigham researchers are closer to being able to predict a patient’s response to multiple prostate cancer therapies at once, with an implantable and retrievable device about the size of a grain of rice. Oliver Jonas, PhD, the inventor of the device, discusses its development and path to regulatory approval.

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Brigham Embraces Tendoscopy for Foot and Ankle Injuries

Rendering of a human ankle showing bones and tendons

While the first tendoscopy procedure was reported in 1995, the minimally invasive but technically challenging approach to addressing various foot and ankle pathologies is not yet commonplace. However, Brigham surgeons including Elizabeth Martin, MD, ScM, are adopting the technique for its patient-centered benefits.

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Reliability of Fifth Metatarsal Base Fracture Classifications and Current Management

X-Ray of foot with fifth metatarsal base fracture highlighted red

Christopher P. Chiodo, MD, at Brigham and Women’s Hospital, and colleagues surveyed foot and ankle surgeons to evaluate the reliability of current classification systems for fifth metatarsal base fractures. They recommend limiting classification to two types.

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Traumatic Brain Injury: a Chronic Disease That Affects More Than the Brain

Scientists and clinicians are starting to recognize links between traumatic brain injury and comorbidities such as cardiometabolic disease. Brigham associate neurologist Saef Izzy, MD, MBChB, discusses what he has observed in studying these links as well as possible implications for clinical care.

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Menopausal Hormone Therapy Linked to Increased Risk of Pituitary Adenoma

Woman sitting down holding a pack of menopausal hormone therapy pills

David J. Cote, MD, PhD, and Meir J. Stampfer, MD, DrPH, of the Channing Division of Network Medicine at Brigham and Women’s Hospital, and colleagues have conducted the first prospective study of associations between pituitary adenoma and the use of oral contraceptives or menopausal hormone therapy.

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