Latest Clinical & Research News
Brigham investigators are examining the link between the microbiota and colorectal cancer, including exploring how bariatric surgery changes the microbiome and the impact this connection may have on the development of colorectal cancer. James Yoo, MD, and Eric G. Sheu, MD, PhD, co-lead this new research initiative.
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Members of the Brigham’s Department of Neurosurgery join other neurosurgical experts at this year’s AANS Annual Scientific Meeting held April 29 – May 2, 2022, in Philadelphia, PA.
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Tracy J. Doyle, MD, Jeffrey A. Sparks, MD, MMSc, and colleagues identified a high prevalence of undiagnosed preclinical parenchymal lung disease in a rheumatoid arthritis cohort, with important clinical implications.
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No standardized risk tool is available for predicting the risk of sepsis in patients who undergo vertebral fracture repair for traumatic spinal injury. To address this knowledge gap, Hasan A. Zaidi, MD, and colleagues explored clinical correlates of sepsis in a large nationwide U.S. cohort.
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In the first study of its kind, Iwona Gabriel, MD, PhD, and Vatche A. Minassian, MD, MPH, of the Urogynecology Group, and colleagues found women and adolescents with surgically confirmed endometriosis are at substantially greater risk than others of having multiple lower urinary tract symptoms.
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Brianne A. Kent, PhD, Steven W. Lockley, PhD, and colleagues hypothesize that peripheral clocks exist in humans. They report that the circadian rhythms of certain peripheral metabolic markers—lipids and liver proteins—differ from that of melatonin, a principal marker of central pacemaker activity.
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Immune checkpoint inhibitor (ICI) therapies have revolutionized the treatment of advanced cancers, but they have a downside. Rheumatologist Deepak A. Rao, MD, PhD, is part of a study examining the rheumatologic manifestation of checkpoint inhibitor-associated arthritis in patients treated with a specific ICI therapy.
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Adam S. Kibel, MD, and Anna Plym, PhD, of the Division of Urology, and colleagues conducted the most comprehensive study to date on the role of inherited DNA damage response (DDR) genes in aggressive prostate cancer. They report high carrier frequency of DDR gene alterations in lethal cases irrespective of ancestry.
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Ali Abbas, MD, MPH, Christopher C. Thompson, MD, MSc, and colleagues report similar technical success rates for endoscopic ultrasound–guided gastroenterostomy (EUS-GE) and surgical gastrojejunostomy, despite more advanced cancer stage and worse performance status in the EUS-GE cohort.
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The Brigham’s Vadim N. Gladyshev, PhD, and colleagues have developed an epigenetic clock that allows predictions of biological age at the single-cell level, pointing to a new direction of aging research with applications for somatic, germline and cancer cells.
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