Latest Clinical & Research News
A study conducted by Daniel Dolan, MD, MPH, Scott J. Swanson, MD, of the Division of Thoracic Surgery, and colleagues determined that even at the Brigham’s high-volume center, low individual esophagectomy volume was associated with a higher perioperative complication rate.
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Brigham researchers recently confirmed that administration of acidified human milk fortifier is associated with higher incidence of metabolic acidosis in the first weeks of life for very-low-birthweight infants, but the type of fortifier was not an important determinant of growth during the NICU stay.
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Ofer Pasternak, PhD, and Johanna Seitz-Holland, MD, PhD, of the Department of Psychiatry at Brigham and Women’s Hospital, and colleagues conducted the first study to compare white matter in 22q-del and 22q-dup, and report finding opposing abnormalities that might indicate distinct pathologies.
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Eli T. Sayegh, MD, Elizabeth G. Matzkin, MD, and colleagues recently set out to define the opioid requirement for all-inside ACLR. They report pain control with a multimodal analgesia regimen that included a limited opioid taper of 15 tablets for five days, which had no negative effect on patient satisfaction.
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Researchers at Brigham and Women’s Hospital examined the two-year natural history of spinal metastases in cancer patients treated operatively or non-operatively and found that both types of treatment yielded improvements in health-related quality of life, but there was no survival advantage with surgery.
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The FREEDOM CVO trial investigated ITCA 650, an osmotic mini-pump that delivers a continuous subcutaneous infusion of exenatide. The primary efficacy outcome met the FDA’s prespecified criterion for noninferiority to placebo in a broad population of patients with T2D.
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Humsa Venkatesh, PhD, a cancer biologist, is studying the neural regulation of cancer and how nervous system cells found within the tumor microenvironment drive tumor growth. Her research has implications for primary brain tumors such as gliomas and for tumors that metastasize to the brain from other parts of the body.
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Mahmoud Dibas, MD, and Adam A. Dmytriw, MD, MPH, MSc, at Brigham and Women’s Hospital, and colleagues used data from a large multicenter study to compare transradial access with transfemoral access for WEB embolization. They report the two approaches were associated with comparable radiologic and clinical outcomes.
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An ion channel protein known as Piezo1 is known to facilitate thrombus formation, and researchers at Brigham and Women’s Hospital have shown it may represent a new target for therapies to prevent thrombosis in patients with type 2 diabetes mellitus who are at high risk.
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In a new study, Stefan G. Tullius, MD, PhD, of the Division of Transplant Surgery, Markus Quante, MD, of University Hospital Tuebingen, and colleagues present evidence that TDCA/valine may be a noninvasive alternative to bariatric surgery for improving transplant outcomes in patients with obesity.
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