Metabolic Syndrome and Its Treatment Affects Response to Androgen Deprivation Therapy in Metastatic Prostate Cancer

3D rendering of prostate cancer cells from top-down view

Adam S. Kibel, MD, and Jiun-Hung Geng, of the Brigham’s Division of Urology, and colleagues recently conducted the first study of how the combination of metabolic syndrome and its treatment affect response to androgen deprivation therapy in castration-sensitive prostate cancer.

Read More...

Cranial Nerve Imaging Abnormalities in Patients With Hereditary Neuropathies Can Mimic Otolaryngologic Problems

Doctor points to brain scan images to detect abnormalities

C. Eduardo Corrales, MD, Ryan A. Bartholomew, MD, and colleagues detected a 21% prevalence of radiologic cranial nerves abnormalities in patients with hereditary neuropathies who underwent MRI. They caution physicians not to assume these findings represent pathologies requiring intervention by an otolaryngologist.

Read More...

Working Outside of the Operating Room to Advance Surgical Care

Headshot of Douglas S. Smink, MD, MPH

Having dedicated his career to patient care, education and research, Douglas S. Smink, MD, MPH, embodies the classic tripartite mission of an academic medical center. He discusses his experience leading the Association of Program Directors in Surgery as well as his research on innovative gastrointestinal training.

Read More...

“Enhanced Recovery After Surgery” Pathway Promising for Cardiac Surgery

Male patient lying in hospital bed recovering from surgery

In 2018, a multidisciplinary team at Brigham and Women’s Hospital developed a multimodal enhanced recovery after surgery (ERAS) program to optimize perioperative care in cardiac surgery. They report promising early results in Seminars in Thoracic and Cardiovascular Surgery.

Read More...

Fundamental Differences Detected Between National Databases in Outcomes of OAAA Repair

Close up of abdominal surgery

Wide variability has been reported in the administrative and quality improvement databases that are used to guide evidence-based decision-making in vascular surgery. A Brigham team detected numerous differences in patient populations and outcomes between three national data repositories using OAAA repair as a model.

Read More...

Pioneering Registry Remains a Driving Force in Rheumatoid Arthritis Research

Nurse walking down staircase with glass walls in background

The Brigham and Women’s Hospital Rheumatoid Arthritis Sequential Study (BRASS) has played an important role in advancing the study of rheumatic arthritis and development of related therapies. Co-principal investigator Michael E. Weinblatt, MD, discusses what this patient registry has helped make possible.

Read More...

Oral Drug Developed at the Brigham Replicates Metabolic Benefits of Gastric Bypass

3d Rendering of gastric bypass on red background

Since many patients with diabetes are ineligible for RYGB or decline it, researchers at Brigham and Women’s Hospital developed an orally administered gut barrier coating for improving glucose homeostasis.

Read More...

Diagnosis Codes Suitable for Researching Obesity Using Claims-based Databases

Physician typing on laptop with clipboard/stethoscope on table

Researchers in the Brigham’s Division of Pharmacoepidemiology and Pharmacoeconomics, led by Elisabetta Patorno, MD, DrPH, have determined obesity-related International Classification of Disease (ICD) codes accurately identify patients with obesity in claims-based data.

Read More...

Insurance Status Correlates With Patient-reported Baseline Symptoms of Spinal Stenosis

Nurse handing insurance card to patient with clipboard on table

Several studies of patients undergoing joint arthroplasty and insured by Medicaid report systematically worse patient-reported outcome measures (PROMs) scores than patients with other insurance. Researchers at Brigham and Women’s Hospital found the same is true among patients with lumbar spinal stenosis.

Read More...

Frailty Status Predicts Mortality After In-hospital CPR

Hands of senior woman resting on cane handle

Ariela Orkaby MD, MPH, of the Brigham’s Division of Aging, and colleagues report that increased frailty status as rated on the Clinical Frailty Scale is associated with increased mortality in older adults after in-hospital cardiopulmonary resuscitation.

Read More...