Novel Transcranial Doppler Screening Approach Identifies Risk of Radiological Delayed Cerebral Ischemia

Transcranial Doppler examination searching for vasospasm after subarachnoid hemorrhage

Samuel B. Snider, MD, Ibrahim Migdady, MBBS, Rose Du, MD, PhD, of Brigham and Women’s Hospital, and colleagues found the severity of transcranial doppler screening-measured vasospasm predicts radiological delayed cerebral ischemia in a vessel-specific manner.

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No Increased Risk of VTE With Tofacitinib vs. TNF Inhibitors in Routine Care

3D Rendering of Tofacitinib Drug Molecule

The Brigham’s Seoyoung C. Kim, MD, ScD, Michael E. Weinblatt, MD, Rishi J. Desai, PhD, and colleagues have analyzed new data that shows no increased risk of venous thromboembolism (VTE) in patients with rheumatoid arthritis who use tofacitinib.

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Improving Microbial Balance in Female Genital Tract May Boost Health Outcomes

Raina Fichorova, MD, PhD, director of the Laboratory of Genital Tract Biology, is a leader in studying host-microbe interactions in the female reproductive tract. Her efforts have included developing a novel “live” biotherapeutic treatment, which she has patented and is now working to bring into clinical trials.

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Preoperative Risk Factors Identified for Prolonged Air Leaks Requiring Intervention

X-ray of patient with upper lung resection

Researchers at the Brigham, including Matthew M. Rochefort, MD, and Aaron R. Dezube, MD, of the Division of Thoracic and Cardiac Surgery, and colleagues retrospectively studied a large series of patients undergoing lung resection to determine the incidence of severe prolonged air leaks and its risk factors.

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Patients Receiving Implanted Devices Need Better Education About Device Documentation, Tracking

X-ray of a permanent pacemaker implant in the chest

A Brigham and Women’s Hospital team reports most patients were unaware of the availability of unique device identifiers for documentation and tracking of their device, and they mistrust having it shared outside the health care system.

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Sinonasal and Asthma Symptom Severities Correlated in Aspirin-exacerbated Respiratory Disease

Woman with asthma uses inhaler

Using prospectively collected registry data, researchers at Brigham and Women’s Hospital linked increased severity of sinonasal symptoms in patients with aspirin-exacerbated respiratory disease to both worse patient-reported asthma control and worse objectively measured lung function.

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One-stage Approach to Converting Laparoscopic Adjustable Gastric Band to Sleeve Gastrectomy Found Safe, Effective

3D rendering of stomach with a gastric band

Scott Shikora, MD, director of Metabolic and Bariatric Surgery in the Center for Weight Management and Wellness at the Brigham, and colleagues conclude one-stage laparoscopic adjustable gastric band to sleeve gastrectomy conversion is safe and effective when performed by experienced surgeons.

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Phase 2a Trial: Monoclonal Antibody Increases Quantity of Functional HDL in Patients With CAD

Color rendering of High-Density Lipoprotein (HDL) particles

Marc S. Sabatine, MD, MPH, and colleagues recently reported the results of LEGACY, a double-blind phase 2a trial of MEDI5884. They observed an increased quantity of functional HDL particles and no adverse safety signal.

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Lower Steroid Dose for Initial Management of Hepatitis Secondary to Immune Checkpoint Inhibitors

3D concept of a human liver with hepatitus virus

Researchers at Brigham and Women’s Hospital conducted the first study to compare the outcomes of different steroid dosing regimens prescribed for patients with high-grade ICI hepatitis. Stephen D. Zucker, MD, Shilpa Grover, MD, MPH, Michael Li, MD, MPH, and colleagues present evidence for starting with the lower dose.

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New Edition of ‘Braunwald’s Heart Disease’ Has Strong Brigham Imprint

stethoscope on a textbook

Brigham cardiovascular specialist Peter Libby, MD, was editor-in-chief of the 12th edition of the iconic textbook “Braunwald’s Heart Disease”, released late last year. He discusses the process of curating a new edition as well as the continued involvement of the founding editor, the Brigham’s Eugene Braunwald, MD.

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