Latest Clinical & Research News
Home hospital programs are a safer, cheaper and more efficacious alternative to inpatient hospital admission for many medical conditions. The Brigham is at the forefront of efforts to extend this delivery model to perioperative care, including for GI and bariatric surgery. Thomas C. Tsai, MD, MPH, discusses this work.
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Intraoperative magnetic resonance imaging is an extremely useful tool in guiding surgical brain tumor resection but also has significant drawbacks. The Brigham’s Department of Neurosurgery is turning to an older alternative: ultrasound. Alexandra J. Golby, MD, director of image-guided neurosurgery, explains.
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The COVID-19 pandemic has dealt a blow to faculty membership and sponsorship programs at many healthcare institutions. In response, the Brigham is piloting a new Faculty Mentorship and Sponsorship Network Program. Laryngologist and associate surgeon Anju K. Patel, MD, who spearheads the program, discusses its impact.
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In the past two years, the COVID-19 pandemic and a renewed emphasis on issues surrounding racial justice have brought the need for trauma-informed healthcare into greater focus. Consultation-liaison psychiatrist Nomi Levy-Carrick, MD, MPhil, has been involved in expanding such programs across more areas of the Brigham.
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Researchers at Brigham and Women’s Hospital have developed a novel brain mapping method that suggests lesions, TMS and DBS converge on a common brain circuit for depression—which may represent a better target for therapeutic neurostimulation. The approach seems to be generalizable to other neuropsychiatric diseases.
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Tracy Young-Pearse, PhD, Valentina Lagomarsino, Richard V. Pearse II, PhD, and colleagues have created a system that fills the gap between autopsy studies and genetic studies. They’ve shown that neurons derived from induced pluripotent stem cells (iPSCs) reflect molecular mechanisms underlying late-onset AD.
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Brigham experts have taken a molecular-driven, single-cell approach to studying the underpinnings of autoimmune diseases—specifically rheumatoid arthritis and systemic lupus erythematosus. Much of the work by Michael B. Brenner, MD, relies on “disease deconstruction,” an approach grounded in discovery-based research.
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Raina N. Fichorova, MD, PhD, and Hidemi S. Yamamoto, BA, of the Laboratory of Genital Tract Biology in the Department of Obstetrics and Gynecology at the Brigham, and colleagues have discovered concurrent exposure to Trichomonas vaginalis and bacterial vaginosis dysregulates the expression of galectins.
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Research at Brigham and Women’s Hospital explored how laparoscopic sleeve gastrectomy improves the systemic inflammatory profile and found pronounced improvement in immune cell composition, function and metabolism, as measured by both biomarkers and gene expression, as soon as three months after the procedure.
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Walter Chan, MD, MPH, director of the Center for Gastrointestinal Motility at the Brigham, Nayna Lodhia, MD, associate physician in the Division of Gastroenterology, Hepatology and Endoscopy, and colleagues have documented anorectal dysfunction in patients with chronic constipation who used opioids.
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