Latest Clinical & Research News
Daniel H. Solomon, MD, MPH, and colleagues have examined data from the Study of Women’s Health Across the Nation to identify several risk factors that might form the basis of a clinically useful risk score, which may point to preventive or therapeutic midlife interventions.
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Deepak L. Bhatt, MD, MPH, of the Interventional Cardiovascular Program at Brigham, and colleagues, recently performed a systematic review and meta-analysis and report that prescription EPA treatment, and not EPA+DHA supplementation, is associated with reductions in cardiovascular mortality and related outcomes.
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Daniel H. Solomon, MD, MPH, Sara K. Tedeschi, MD, MPH, and colleagues surveyed patients with systemic rheumatic disease (SRD) about their attitudes toward COVID-19 vaccination. They report high interest and a high trust in physician recommendations about vaccination.
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A 77-year-old woman, whose past medical history included type 2 diabetes, end-stage renal disease and hypertension, presented to the emergency department with a two-month history of severe left ear and facial pain. Imaging demonstrated changes in soft tissue and bone that were concerning for skull base osteomyelitis.
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Francisco J. Quintana, PhD, Cristina Gutiérrez-Vázquez, PhD, and colleagues engineered yeasts that generate an immunosuppressive molecule in direct proportion to the amount of a pro-inflammatory metabolite produced in the inflamed gut. They describe their new treatment platform and the results.
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Using the world’s largest pharmacovigilance database, Eugene B. Cone, MD, Quoc-Dien Trinh, MD, and colleagues determined the risk of cardiac adverse events is increased substantially with abiraterone and not at all with enzalutamide.
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Lisa Cooper, MD, and Houman Javedan, MD, of the Division of Aging at the Brigham, and colleagues have adapted the comprehensive geriatric assessment (FI-CGA) tool to be feasible for use by geriatricians to communicate complex geriatric concepts with multiple other clinics at the Brigham that care for older adults.
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A retrospective study at the Brigham, led by Lisa Cooper, MD, and Laura N. Frain, MD, MPH, found that polypharmacy, potentially inappropriate medications, and frailty were not associated with complications after surgery for thoracic malignancies, but frailty was associated with increased length of hospital stay.
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By studying how cells from healthy normal weight and overweight participants broke down carbohydrates in real time, researchers including Brigham obesity medicine specialists Nawfal W. Istfan, MD, PhD, and Caroline M. Apovian, MD, have uncovered clues about what triggers metabolic distress.
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Souheil Y. El-Chemaly, MD, and Julie Ng, MD, of Brigham and Women’s Hospital, and colleagues conducted the first study to examine the lung microbiome of patients with lymphangioleiomyomatosis (LAM) who were at high risk of disease progression or death.
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