Latest Clinical & Research News
By taking the brakes off the immune system and allowing it to attack cancer cells, checkpoint inhibitors have spurred significant advances in the treatment of many people with cancer over the past decade. But for patients who do not respond to these drugs — still the majority of people with cancer — alternative interventions are needed.
While clinicians have several tools at their disposal to determine whether patients are delirious, researchers at the Brigham are going a step further by focusing on the severity of delirium. Geriatrician Tammy T. Hshieh, MD, MPH, discusses a more nuanced delirium rating tool featured in a recently published study.
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Emily Moldoff, NP, Carleton Eduardo Corrales, MD, and Jennifer J. Shin, MD, and colleagues have documented that the noise generated by powered air-purifying respirators creates a substantial barrier to communication during clinical interactions.
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By using a newer technique called lesion network mapping, Michael Ferguson, PhD, Michael D. Fox, MD, PhD, of the Center for Brain Circuit Therapeutics at Brigham and Women’s Hospital, and colleagues have identified a specific brain circuit that seems to be a neural substrate for spirituality and religiosity.
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In a nationwide online survey of pregnant and postpartum women, Cindy H. Liu, PhD, and Carmina Erdei, MD, of Brigham and Women’s Hospital, and colleagues determined that psychological factors related to COVID-19, particularly grief, pose unique hazards to mother–infant bonding.
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Several studies in predominantly older white populations have identified various risk factors for early COPD such as asthma. Now, Fariha Khalid, MD, MPH, Alejandro A. Diaz, MD, MPH, of Brigham and Women’s Hospital and colleagues have conducted one of the largest studies of early COPD in U.S. Hispanics/Latinos.
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Jose R. Romero, PhD, and colleagues have now used a prevous model of patients with rs2540923 to show that striatin serves a protective role in the hemostatic system, which may be reduced in humans with striatin risk alleles.
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Andrew J. Schoenfeld, MD, orthopedic surgeon at Brigham and Women’s Hospital, Elena Losina, PhD, co-director of the Brigham’s OrACORe, and colleagues conducted the first cost-effectiveness analysis of surgery for spinal metastases that accounts for ambulatory function at presentation.
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Gordon H. Williams, MD, senior physician in the Division of Endocrinology, Diabetes and Hypertension at the Brigham, Shadi K. Gholami, PhD, research fellow, and colleagues have expanded on their earlier work to determine if biological sex affects the production of aldosterone levels.
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David E. Cantonwine, PhD, of the Division of Maternal–Fetal Medicine at Brigham and Women’s Hospital, and colleagues recently conducted the first study of PFAS and preeclampsia that distinguished between early- and late-onset preeclampsia, which have different risk factors, severities and pathophysiologies.
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