Bioinformatics Core Supports Investigators Who Seek to Use Big Data

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Bioinformatics methods are increasingly applied in clinical research studies to approach research questions from novel perspectives. For example, natural language processing (NLP) enables use of information previously embedded in narrative clinical notes. Leveraging experience from the past decade in developing and applying bioinformatics tools for clinical studies, the VERITY Bioinformatics Resource Core supports investigators who seek to apply these tools to their research in rheumatic and musculoskeletal disease.

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Join the VERITY Research Community

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Pediatric and adult rheumatic and musculoskeletal diseases challenge the clinical researcher:

  • They affect the population across the lifespan,
  • They impact a broad range of patient-centered outcomes,
  • They are rarely cured, and
  • They often have multiple possible treatment strategies.

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Methodology Core Finds the Optimal Study Design for Your Innovative Research Idea

figure 1. Methodolic approaches to clinical priority areas

The VERITY Methodology Core addresses many complex methodologies that researchers encounter when studying rheumatic and musculoskeletal (MSK) disorders. These conditions persist for decades and have a profound impact on the patient’s quality of life. Epidemiologic studies to identify persons at high risk for these disorders and to identify factors leading to worse prognoses merit a high priority, and clinical trials to establish treatment efficacy are even more crucial. Both types of studies must account for the complexity of the phenotype and longevity of the clinical course. Furthermore, they must address the balance between efficacy and toxicity in treatments for rheumatic and MSK disorders.

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VERITY Enrichment Core Offers Weeklong Brigham Course in Rheumatology Clinical Research

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In May 2018, 15 trainees and junior faculty in adult and pediatric rheumatology from across the United States arrived at Brigham and Women’s Hospital in Boston for the inaugural VERITY/Brigham Course in Rheumatology Clinical Research. The course is aimed at early stage investigators in rheumatology and musculoskeletal diseases who are performing clinical, epidemiologic or patient-oriented research studies.

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Identifying and Combating the Dangers of ADT in Prostate Cancer Patients

Micrograph of metastatic prostate carcinomaThe modification of the androgen axis plays a central role in men’s health, from maintaining vitality to controlling prostate cancer. Trying to balance the side effects and benefits of altering this axis is a fertile area of research.

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Expanding the Frontiers of Care for Pancreatic Diseases

3D Illustration of Human Body Organs Anatomy (Pancreas)For 26 years, the Center for Pancreatic Disease at Brigham and Women’s Hospital has been at the forefront of providing care for patients with pancreatic diseases. The Center’s three medical pancreatologists, who include Peter A. Banks, MD, Julia Y. McNabb-Baltar, MD, MPH, and David X. Jin, MD, MPH, work collaboratively with interventional radiologists, gastrointestinal surgeons and therapeutic endoscopists to provide the latest diagnostic and treatment options for acute and chronic pancreatitis, pancreatic cysts, hormone-producing tumors and cancer.

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New Enhanced Recovery Pathway After HIPEC Improves Outcomes

Concentrated female surgeon performing surgery with her team in hospital operating room. Medics during surgery in operation theater.A treatment option that has shown to improve clinical outcomes and prognosis in patients with peritoneal metastasis is cytoreductive surgery with hyperthermic intraperitoneal chemotherapy (HIPEC). While HIPEC can improve disease-free survival in many patients, it’s a major operation.

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Are Dialysis’s Days Numbered?

Human kidney cross section on scientific backgroundIn the 1960s, Brigham and Women’s Hospital pioneered the development and commercialization of dialysis. Once again, the Brigham is on the forefront of renal replacement therapy (RRT) through a new project spearheaded by the Kidney Health Initiative (KHI), a public-private partnership between the American Society of Nephrology (ASN), the U.S. Food and Drug Administration, patients, academia and industry to identify and create solutions for vexing problems in kidney disease.

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Reversing Type 2 Diabetes With a Pill Rather Than Gastric Bypass Surgery

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Illustration by Randal Mckenzie

Over the past decade, gastric bypass surgery has been proven to reverse not only obesity but also type 2 diabetes in patients with both conditions. However, most diabetic patients do not meet current surgery criteria. And of those who do, fewer than two percent actually proceed due to concerns about risks.

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Proactive Psychiatric Consultations Benefit MICU Patients

ECG and ultrasonic monitoring of cardiac function with flashing light in the end of hospital hallway.Preexisting mental illness and substance abuse disorders are common in patients being treated in intensive care units (ICUs), as is delirium. There is increasing appreciation for the impact of these conditions on overall health outcomes, length of hospital stay and mortality.

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