Latest Clinical & Research News
Five years ago, Wolfgang Fitz, MD, a knee replacement surgeon in the Department of Orthopaedic Surgery, asked his patients to bridge the two-to-three months prior to surgery with physical conditioning, tailored to their activity levels and knee osteoarthritis.
There’s a growing interest in finding strategies to increase physical activity in patients who have undergone total knee replacement (TKR). In a clinical trial, Brigham and Women’s Hospital researcher, Elena Losina, PhD, and colleagues showed that one-on-one health coaching and financial incentives substantially increased physical activity in patients following TKR. The results were published in the April 2018 issue of Arthritis Care & Research.
Consultation-Liaison (C-L) Psychiatry has been an important component of psychiatry for over 70 years and a certified subspecialty under the American Board of Medical Specialties since 2004. Brigham and Women’s Hospital has one of the largest C-L divisions and one of the largest C-L fellowship programs in the country, with a mission to maintain strong bonds between psychiatry and other specialties of medicine.
Elizabeth A. Mittendorf, MD, PhD, a breast cancer surgeon and international leader in breast cancer vaccines, recently joined Brigham and Women’s Hospital (BWH) from the MD Anderson Cancer Center in Houston, where her research focused on vaccines that target the HER2 protein expressed on many breast tumors. At the Brigham, her work focuses on advancing our understanding of breast cancer immunotherapies.
Image courtesy of INSIGHTEC
Each week, two or three patients with medically refractive essential tremor undergo MRI-Guided Focused Ultrasound (MRgFUS) Thalamotomy at Brigham and Women’s Hospital, with often-life-changing results – fulfilling the promise of a technology that dawned here 20 years ago.
As the American population ages, a greater percentage of people will suffer from moderate to severe hearing loss. Research shows that older people also are at a higher risk of accidental injuries.
Cerebrospinalfluid (CSF) leaks in the lateral recess of the sphenoid (LRS) are rare. For cases in which they do occur, however, Brigham and Women’s Hospital offers a minimally invasive, endoscopic alternative to traditional open surgery.
In the face of America’s growing opioid crisis, Brigham and Women’s Hospital has introduced an innovative new service to help patients with addiction abuse disorder get the immediate care they need. Opened in spring 2018, the Bridge Clinic immediately connects patients being discharged from the hospital and emergency department with treatment and services.
A drug whose clinical testing was led by Toni K. Choueiri, MD, of Dana-Farber/Brigham and Women’s Cancer Center (DF/BWCC), has become a standard first-line therapy for certain newly diagnosed patients with advanced kidney cancer. Additionally, several combination therapies are being used or tested at DF/BWCC and elsewhere against this aggressive cancer.
Read More
Prior work in Lupus Nephritis has shown that immune cell infiltration, especially that of monocytes, is associated with pathologic tissue remodeling and declining renal function. A deeper understanding of infiltrating monocytes could yield more accurate interpretations of histopathologic lesions, better disease predictors, and new therapeutic concepts. Newer technologies offer a promising path toward this goal. Single cell-RNA sequencing (scRNA-seq) enables the molecular classification of cell states based on the expression of thousands of genes, and multiplex-immunofluorescent imaging enables precise spatial localization of these cell states in the context of diseased tissue. Groundwork to merge these technologies derives from our work with the Accelerating Medicines Partnership (AMP) consortium.
Read More